Although the adverse effects related to the ketogenic diet are generally less serve than those of anticonvulsant medications used to treat epilepsy, individuals following the diet may experience a number of undesirable effects.
Short-Term Side Effects
There are several short-term side effects that are most evident at the beginning of therapy, particularly when patients commence the diet with an initial fast.
Hypoglycemia is a common side effect in this instance, and noticeable signs may include:
- Excessive thirst
- Frequent urination
- Fatigue
- Hunger
- Confusion, anxiety and/or irritability
- Tachycardia
- Lightheadedness and shakiness
- Sweating and chills
Additionally, patients may also experience some constipation and low-grade acidosis. These effects tend to improve when the diet is continued, as the body adapts to the new diet and adjust the ways in which it sources energy.
Alteration in Blood Composition
As a result of the changes in dietary consumption and the body’s adaptive mechanisms to cope with the reduced carbohydrate intake, there are several changes in the blood composition of individuals following the ketogenic diet.
In particular, the levels of lipids and cholesterol in the blood are commonly higher than what is considered to be normal. More than 60% of patients have raised lipid levels and more than 30% have high levels of cholesterol.
If these changes are profound and there is some concern about the health of the child, slight changes to the diet can be made for the individual patient. For example, saturated fat sources can be substituted for polyunsaturated fats. In some cases, it may be necessary to lower the ketogenic ratio and reduce the proportion of fat to carbohydrate and protein in the diet.
While the ketogenic diet may seem new and trendy, it’s actually been around since the 1920s as a treatment for epilepsy. Nowadays, it’s touted as a remedy for everything from infertility to type 2 diabetes, and with helping folks drop those stubborn extra pounds.
“The keto diet can certainly be effective for quick weight loss,” says Kim Yawitz, RDN, a dietitian in private practice in St. Louis. “Weight loss of up to 10 pounds in just a couple of weeks is common, although some of this is water weight.”
The ketogenic diet typically reduces carbohydrate intake to less than 50 grams per day — and calls for increased protein and fat intake, according to a review published in August 2013 in the European Journal of Clinical Nutrition. Roughly speaking, on keto you’ll get 70 to 80 percent of your calories from fat, about 20 percent from protein, and as little as 5 percent from carbs.
The diet is extremely regimented and very difficult to stick to, as just one baked potato and one slice of bread could hold an entire day’s worth of carbohydrates. While this is a deterrent for many, Christy Brissette, RD, a private-practice dietitian in Chicago, notes that many of her patients like the diet because of its strictness. “Some of my clients feel that the keto diet works for them because it doesn’t involve any calorie counting and the rules are simple to understand,” she says. “They feel they have strict parameters that can take the guesswork out of dieting.”
Adherence to a keto diet food list isn’t always great, though. A review published in January 2015 in the Journal of Clinical Neurology found that only 45 percent of participants were able to follow the approach as prescribed. “The poor compliance was attributed to side effects, social isolation, and cravings,” says Yawitz. And some people in the study “reported the diet simply wasn’t helping them lose weight,” she adds. Brissette agrees with this line of thinking. “In my opinion, the keto diet isn’t sustainable and takes the joy and fun out of eating,” she says.
As you can see, there are many potential benefits and side effects of the ketogenic diet. Here, we’ll delve into 11 potential dangers of the keto diet that any beginners considering the approach need to know.
1. Serious Muscle Loss Is a Possible Side Effect of Keto
“Muscle loss on the ketogenic diet is an ongoing area of research,” says Edwina Clark, RD, a dietitian in private practice in San Francisco. “Small studies suggest that people on the ketogenic diet lose muscle even when they continue resistance training. This may be related to the fact that protein alone is less effective for muscle building than protein and carbohydrates together after exercise.” Meanwhile, according to a small study published in March 2018 in the journal Sports, people following the keto diet for three months lost about the same amount of body fat and had about the same muscle mass changes as people following normal diets. Yet the folks on keto did lose more leg muscle.
“Loss of muscle mass as we age has a number of serious consequences,” notes Clark. “Muscle is metabolically active and helps boost daily energy expenditure and mitigate age-related weight gain.” Losing muscle mass can also decrease functional strength and heighten the risk of falls, notes Clark. Falls are the top cause of death from injury in older populations, according to the Institute of Medicine Division of Health Promotion and Disease Prevention.








